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KMID : 0369820040340030169
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Jorunal of Korean Pharmaceutical Sciences
2004 Volume.34 No. 3 p.169 ~ p.176
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Preparation and In Vitro Test of Solid Dispersion using Acyclovir and Water Soluble Polymer
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안용산/Ahn YS
이하영/홍금덕/정성범/조선행/이종문/이해방/강길선/Lee HY/Hong KD/Jung SB/Cho SH/Rhee JM/Lee HB/Khang GS
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Abstract
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Acyclovir(ACV) is an important antiviral drug used extensively against infections caused by herpes viruses, especially herpes simplex and varicella zoster. Because of high crystallinity and large particle size, solubility of intact ACV is very low in water(1.3 mg/ml). The goal of this work is to enhance the solubility of ACV. To make solid dispersion, Polyethyleneglycol, Hydroxyprophylmethylcelluose and Polyvinylpyrrolidone were used as polymer carriers in this work. Polymer carriers and drug were dissolved in acetic acid. And then spray drying method and freeze drying method were used as solvent extraction. Morphology, crystallization and functional group were characterized using SEM, XRD and FT-IR. The result of in vitro test showed the sample using PVP as polymer carrier had higher dissolution rate(up to 466%) than intact ACV.
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KEYWORD
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Acyclovir, Sold dispersion, Polymer carriers
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